Our cross-disciplinary working group galvanises collaborations and is a focal point for anyone planning to move into 3-D cell culture modelling and train PhD students.

As researchers at Southampton General Hospital, we are privileged to have access to clinical samples directly from patients. Once collected, samples are sent to a biorepository such as a tissue bank, or they get processed for integrated multiomic analysis. Our approach answers research hypothesis and creates new ones – either way, a lab with expertise in advanced cell culture platforms is crucial.

These modelling platforms are also a tool to identify new interventions and drugs leading to innovative trial designs.

Under the NIHR Southampton Biomedical Research Centre respiratory theme, we have an ā€œAdvanced cell cultureā€ programme. Our first action was to set up SoCRATES.

Creating a cross-disciplinary advanced cell culture group facilitating the development of 3D models of disease.

Utilising ex-vivo models to accelerate identification of new therapeutic approaches. Understanding host-pathogen interaction and drug discovery.

Embracing expertise and encouraging collaboration across the University of Southampton, other academic centres and industrial partners.