Meet Emily Gwyer Findlay
Dr Emily Findlay is interested in how the innate and adaptive immune systems interact, particularly in human inflammatory disease. She particularly studies neutrophil and T cell interactions in inflammatory bowel disease and multiple sclerosis.
Dr Findlay’s team study human lymph nodes, blood, intestinal tissue and post-mortem brain to understand how these interactions occur and how they alter cell behaviour in chronic disease. They use a variety of models such as live lymph node slice cultures, immunofluorescence and flow cytometry analysis, metabolic analysis and spatial and single cell transcriptomics to answer these questions.
Neutrophilic infiltration of lymph nodes increases throughout the development of inflammatory disease. Inguinal lymph nodes showing pink neutrophil migration (staining for the granule peptide cathelicidin) during time course of the mouse model of Multiple Sclerosis, EAE. They want to use slice cultures of these nodes to understand where the neutrophils move to, and what impact they have on the development of T cell immunity in the nodes
